In vivo polysialylation to enhance the pharmacokinetic profile of therapeutic proteins and immunomodulation



polysialic acid, polysialylation, glycopolymer, plant expression system

Kurzbeschreibung:
An important factor for the clinical and commercial success of protein based drugs lies in optimal bioavailability, which is a major challenge for pharmaceutical industry. It has been shown that Polysialic acid (PolySia), large negatively charged sugar chains, has the ability to modulate protein pharmacokinetics, bio-distribution and bioavailability. In addition, PolySia contributes to anti-inflammatory processes.

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