Biocatalytic production of NADH and aromatic/aliphatic aldehydes

Biotechnological processes are essential methods for the sustainable production of numerous types of chemical compounds, base chemicals as well as functionalized specialty chemicals. For the efficient run of fermentation processes it is generally also very supportive to provide sufficient supply of NADH, the universal „energy compound“ for nearly all biological processes in cells. The invention presented herein provides a biocatalytic (enzymatic) process for the reduction of either carboxylic acids (primarily providing aldehydes and subsequently alcohols) or NAD+ (providing NADH). The process is using the enzyme aldehyde oxido-reductase (AOR, left) as bio-catalyst and requires only hydrogen as readily available and cheap reductant.


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